RESUMO
Pregnant rats were intubated with alcohol throughout gestation. Control animals received vehicle and were pair-fed. At birth, all offspring were surrogate-fostered to nontreated dams. At 11 weeks of age, alcohol-exposed animals did not perform as well in a two-way shock avoidance task. The brains of these animals also exhibited significant deficits in dendritic structure in the area of the hippocampus. These behavioral observations may be a counterpart to the learning deficits associated with fetal alcohol effects, e.g., fetal alcohol syndrome in humans and animals, and the neuroanatomical observations suggest a structural basis for these learning deficits.
Assuntos
Aprendizagem da Esquiva/efeitos dos fármacos , Etanol/toxicidade , Transtornos do Espectro Alcoólico Fetal/fisiopatologia , Hipocampo/patologia , Animais , Modelos Animais de Doenças , Feminino , Transtornos do Espectro Alcoólico Fetal/psicologia , Hipocampo/efeitos dos fármacos , Masculino , Neurônios/efeitos dos fármacos , Gravidez , Tratos Piramidais/efeitos dos fármacos , Tratos Piramidais/patologia , RatosRESUMO
A semipurified liquid diet was used to develop a chronic rat model of fetal alcohol syndrome. Adult female rats were fed a control or 40% ethanol (percent of total caloric intake) liquid diet. Additional controls were pair fed to the 40% experimental group. Results of the effects of these diets on the offspring included both qualitative and quantitative changes observed in Golgi study of hippocampal pyramidal neurons.
Assuntos
Transtornos do Espectro Alcoólico Fetal/patologia , Animais , Peso ao Nascer/efeitos dos fármacos , Peso Corporal/efeitos dos fármacos , Dendritos/patologia , Modelos Animais de Doenças , Feminino , Transtornos do Espectro Alcoólico Fetal/mortalidade , Hipocampo/patologia , Tamanho da Ninhada de Vivíparos , Gravidez , Efeitos Tardios da Exposição Pré-Natal , RatosRESUMO
A semipurified liquid diet was used to develop a chronic rat model of the fetal alcohol syndrome. Control female rats gained weight normally, reproduced normally, and gave birth to normal litters on this diet. Increased neonatal mortality, decreased neonatal weights, and altered sex ratios were observed in offspring of experimental alcoholic animals. Preliminary histological results include a mild delay in cell lamination patterns in the cerebral cortex at 4 days postnatal in alcoholic offspring as well as decreased formation of dendritic spines at 7 days postnatal.
